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pentobarbital will reduce the level or effect of eplerenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Unknown.Contraindicated (one)pentobarbital will decrease the extent or effect of cariprazine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. CYP3A4 is to blame for the developm